The Interplay of CBD and Mitochondria

The Interplay of CBD and Mitochondria


For years, scientists have been studying the link between mitochondria and health, but recent research has made it clear that there is a strong connection between CBD and mitochondrial function. Understanding how this works can give you an idea of how cannabis can affect your body and how to use it to optimize your health.


CBD has been shown to affect mitochondrial function positively by affecting the mitochondria directly and indirectly through its interactions with the endocannabinoid system.


CBD has been shown to have a positive effect on mitochondrial function. This can be explained by its ability to increase the activity of SIRT1, an enzyme that promotes healthy aging and energy production in mitochondria.

It also affects the mitochondria indirectly through its interactions with cannabinoid receptors or the endocannabinoid system (ECS). The ECS is made up of various receptors that are activated by phytocannabinoids such as CBD, THC, or endocannabinoids like anandamide (which naturally occurs in our bodies). When activated by these compounds, they lead to a chain reaction that stimulates our body’s natural production of these molecules which then travel around our body activating other receptors.

CBD has also been shown to be a potent antioxidant in studies involving mice with Huntington's disease—a genetic condition where neurons degenerate leading them to die off at rapid rates resulting in severe neurological impairment and even death due to lack of muscle control or organ failure caused by damaged cells dying faster than new ones can replace them."


Studies have found mitochondria-CBD links in a variety of health conditions

CBD, or cannabidiol, has been shown to help with a variety of health conditions. For example:

  • Cancer: Several studies have found that CBD can reduce the size of tumors in mice and rats.

  • Brain injury: A 2013 study published by The American Journal of Pathology found that CBD promotes neural regeneration in rats after traumatic brain injury.

  • Epilepsy: Studies have shown that CBD may be effective at reducing seizure frequency among patients with Dravet syndrome or Lennox-Gastaut syndrome (types of severe infantile epilepsy).