The remarkable findings of this 2022 study suggest that CBD could potentially address various deficiencies and health conditions independently, negating the requirement for multiple different supplements to achieve similar results.
The versatility of CBD in modulating various physiological processes also suggests that CBD may have advantages over other supplements, which often target only one specific pathway.
These results point to the possibility of CBD serving as a versatile, multi-functional supplement, providing comprehensive health support in a single, natural source.
The significant increase in vitamin D3 receptor protein expression in the liver, kidney, and brain, along with the improvement in spatial memory, reduction in cytokines, and increase in antioxidant levels, clearly indicates the broad range of benefits offered by CBD.
Overall, the study represents a significant step towards understanding the complex interplay between CBD, vitamin D3, and the endocannabinoid system, and its potential implications for various health conditions.
Key points from the study:
✅Vitamin D3 receptor protein expression was significantly increased by 148.3%, 60.48%, and 142.03% in liver, kidney, and brain, respectively, compared to VDD group.
✅Vitamin D3 metabolites and serotonin were significantly increased more than 60% and 100%, respectively, compared to VDD.
✅Spatial memory (in terms of total distance, escape latency) and pain score were improved compared to VDD.
✅Cytokines were significantly reduced than VDD.
✅Levels of superoxide dismutase (49.61%), glutathione peroxidase (178.87%), acetylcholine (25.40%), and klotho (145.57%) were significantly increased than VDD.
Study Title: Effects of Cannabidiol Interactions with CYP2R1, CYP27B1, CYP24A1, and Vitamin D3 Receptors on Spatial Memory, Pain, Inflammation, and Aging in Vitamin D3 Deficiency Diet-Induced Rats
Study Link: https://pubmed.ncbi.nlm.nih.gov/35443806